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Canonically, cGAS catalyzed the formation of cGAMP and facilitated cGAMP binding to STING

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Ahire et al., 2021)

The latter could partly explain the lack of replication of the association between this marker and ET in Latvian, Russian, Belarusians, Ukrainians, Polish, Lithuanians [ 64 ], Asians [ 65 ], Italians [ 66 ], Germans, Danish, French [ 67 ], and overall Caucasians [ 68 ]