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The economist Alex Tabarrok has written that when an approved drug harms people there are front-page stories, but when the FDA fails to approve a good drug

Generally, weight loss of greater than 24% of initial body weight and at a rate greater than 1.5 kg (about 3.3 pounds) per week has been identified as a risk factor for gallstones, but the risk may be mitigated by controlling the rate of weight loss, reducing the length of the overnight fast, and keeping a small amount of fat (at least 7 grams per day) in the diet to improve gallbladder motility (Erlinger 2000)

The Lancet 365 , 12311238 (2005)

10.3389/fnmol.2017.00182 155 ShunguD