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Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair-deficient mice

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The acetylation of GATA4 increases its DNA binding activity and the transcription of cardiac hypertrophic response genes, including atrial natriuretic factor (ANF), brain natriuretic peptide (BNP), endothelin-1 (ET-1), and -myosin heavy chain (-MHC), leading to cardiomyocyte hypertrophy [8, 9, 10]

The results were extraordinary: Retatrutide 1mg: 42.9% reduction in liver fat at 24 weeks Retatrutide 4mg: 57.0% reduction Retatrutide 8mg: 81.4% reduction Retatrutide 12mg: 82.4% reduction Placebo: 0.3% increase By 48 weeks, 89% of participants on 8mg and 93% on 12mg had achieved normal liver fat levels (below 5%)