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After 12 days of cultivating spermatogenic cells in a collagen-based gel matrix, round spermatogonial cells were observed, indicating that spermatocytes could be induced to differentiate into putative spermatids in vitro [202]

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Administration of DTA (25 or 50 ng/g, 2 x, i.p.) to CCl 4 -injured Lrat YFP-Col1a1-DTR mice caused ablation of aHSCs within 24h in a dose dependent manner (60% to 90%, respectively), as shown by the disappearance of YFP + Desmin + cells, and downregulation of Col1a1, YFP, DTR, and Cre mRNA, and attenuation of liver fibrosis at 3 days

This can culminate in geographical atrophy which are accumulations of atrophic RPE and photoreceptor cells causing loss of vision (265)