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Genetic susceptibility plays a key role

The impact of APOE on neuronal energy metabolism has already been shown

Tofacitinib, baricitinib, and ruxolitinib are among the JAK inhibitors currently investigated to determine whether they can treat COVID-19 (e.g., NCT-04332042, NCT-04348695, NCT-04321993, and NCT-04348695) (Peterson et al., 2020)