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Introduction Allergic rhinitis (AR) is a non-infectious disease of the nasal mucosa mediated primarily by immunoglobulin E (IgE) following allergen exposure ( Epigenetic modifications, including histone acetylation, have been implicated in the pathogenesis of AR ( Epithelial tight junctions (TJs) are macromolecular complexes composed of transmembrane proteins (e.g., Occludin, JAMs, Claudins) and cytoplasmic plaque proteins (e.g., Zonula Occludens, ZOs)

doi: 10.1038/s41581-019-0234-4 7 KongLAndrikopoulosSMacIsaacRJMackayLKNikolic-PatersonDJTorkamaniNet al