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The natural cell environment of all living systems is reducing and this state is, for the most part, maintained through the action of certain enzymes which constantly provide a source of metabolic energy

In BCAP-deficient mice, these defects could be rescued by exogenous lactate, confirming that histone Kla and reparative programs can be restored through lactate supplementation, with increased Arg1 and Klf4 expression serving as key markers of this transition [173]