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In PD and DLB, outlier counts are also higher in patients with dementia, and correlate with worse cognition 126

Because Theta class GSTs were present in bacteria, the first model of evolution, dating from the early 1990s, proposed that canonical (soluble) GSTs of plants, animals, and fungi have evolved from this ancestral gene as a result of duplications followed by divergent evolution (Pemble and Taylor, 1992)

Song Y, Hupfeld KE, Davies-Jenkins CW, Zllner HJ, Murali-Manohar S, Mumuni AN, et al

Additional sequences were added to the alignment using a combination of Blast searches (Altschul et al., 1990) of Uniprot, and joining of additional 50% sequence identity (ID) clusters to provide further evolutionary depth when necessary