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Multiplexed quantitative proteomics typically refers to workflows in which peptides are labeled with isobaric mass tags such as iTRAQ or TMT (Figure 4) (Pappireddi et al., 2019

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Although the decrease in GSH alone is not responsible for the degeneration of glial cells and neurons, reduced GSH could increase the susceptibility to other stressful factors and contribute to neuronal damage at glia and neuron cells