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The study reports a significant association between lung cancer (LC) and suggests that the anemia observed in LC patients is not primarily due to diminished erythropoiesis, but rather to an increased turnover of erythrocytes

Mikucki and Kahler, 2023)

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Hepatic effects that are considered adverse include death, abnormal clinical chemistry parameters, obvious functional organ impairment, DNA and mitochondrial alteration, glutathione depletion, hepatocyte necrosis, enhanced replicative DNA synthesis, generation of reactive oxygen species, and increased peroxisome proliferation (in rodents) (Williams and Iatropoulos 2002)