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However, in tumor cells, ROS-induced autophagy activation can promote cell development and cancer progression ( The Nrf2-dependent adaptive response, which includes phase II detoxifying enzymes, antioxidants, and transporters that protect cells from further carcinogenic assaults, is how chemopreventive substances or synthetic chemicals carry out their chemopreventive action

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Specifically, SOD facilitates the conversion of superoxide anions into hydrogen peroxide, which is subsequently broken down by CAT and GSH-Px