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It has an increased risk of renal failure

Practical recommendations: If you have a confirmed B12 deficiency requiring high-dose supplementation, a standalone B12 product is usually sufficient

The essential nature of GPX4 is demonstrated by the fact that genetic disruption of the entire Gpx4 gene in homozygous Gpx4 knockout causes in utero fetal death by midgestation (Imai et al., 2003)