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Crosstalk between metabolism and inflammation in dry age-related macular degeneration

Sadek et al

In addition to different signal strength, the distinct conformation of c-MET triggered by different types of ligand may allow it to preferentially activate different downstream signaling pathways through engaging distinct sets of downstream effectors, which is reminiscent of the biased agonism paradigm established for other RTKs, such as EGFR 35