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Development of selective androgen receptor modulators (SARMs) Selective androgen receptor modulators (SARMs) are tissue-specific activators of the androgen receptor (AR) that offer the therapeutic benefits of androgens with fewer side effects

There were 2 large human trials with 117 and 320 patients each, but neither showed any benefits after 7-10 days of administration

If a protocol adds frequency or increases dose without a clear reason, the study may stop testing a clean pulse-based design and start testing accumulation of procedural stress