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Somasundaram S, Sigthorsson G, Simpson RJ et al (2000) Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID-enteropathy in the rat

One example is zonation of LSECs morphology which shows larger and more porous cells in the pericentral zone of rats, potentially facilitating filtration of toxins ( One of the difficulties in mapping any potential zonation profile of non-parenchymal cells in the liver is due in part, to the high abundance of hepatocytes masking any heterogeneity of less abundant cell types

Consequently, this intricate network of feedback and feed-forward loops adjusts the transcriptional landscape, influencing disease progression