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Description

Ickowicz S, McLean M

doi: 10.1002/j.2040-4603.2016.tb00690.x 13

Through systematic identification of pivotal hub genes (NQO1, AURKA, and CDKN2A), this study has not only elucidated the synergistic mechanisms underlying the ferroptosis-cuproptosis regulatory network in HNSCC progression, but also characterized the clinically resistant Epi_2 molecular subtype with distinct therapeutic vulnerabilities

Within this framework, iron accumulation may signal heightened susceptibility to ferroptosis, reflecting defective iron mobilisation and organellar crosstalk rather than simply a reservoir of pro-oxidant potential