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Bipolar affective disorder (BPAD) is associated with malfunctioning oxidative systems, whereas antidepressants appear to protect oxidative systems and protect nerve cells from harm caused by oxidative damage

Upon activation, the Hippo pathway triggers the phosphorylation of the MST1/2-salvador1 (SAV1) complex via upstream activators, including neurofibromatosis 2 (NF2), RhoA and Kibra

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This is important because unchecked oxidative stress is associated with so many diseases including cancers, neurodegenerative diseases such as Parkinsons and Alzheimers, and heart disease that it can aptly be considered a killer