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Description

Thiol-based regulation of redox-active glutamate-cysteine ligase from Arabidopsis thaliana

Cholestatic liver diseases, such as primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC), are lack of effective therapy and with huge unmet medical needs

doi: 10.1016/j.molcel.2017.12.021 37 ReniereM

Researchers investigate its role as a cofactor for glutathione peroxidase and S-transferase enzymes, and examine its involvement in xenobiotic metabolism and heavy metal chelation pathways in cell cultures