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Regarding small molecule inhibitors targeting NNMT, challenges include the identification of efficient and selective inhibitors with robust in vivo activity (Barrows et al., 2022)

Tamoxifen binds to ER, the ER/tamoxifen complex recruits other proteins known as co-repressors, and the complex then binds to DNA to modulate gene expression

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The new plasmids necessary to reproduce the work have been deposited at Addgene ( Source data are provided with this paper