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"No bloodwork" model reduces clinical data: While convenient, the standard protocol of skipping baseline lab work means you lack objective markers (IGF-1 levels, metabolic panels) to monitor therapy effectiveness or safety over time

Figure 2 2.2.1 CD8+ T cells CD8+ T cells, key immune effector cells in the TME, are involved in tumor clearance, as well as in responding to viral infections and other pathological conditions (56)

To validate the cellular dependency on DCAF16-Cys58, we generated a homozygous C58S knock-in mutation of DCAF16 in MCF-7 cells using CRISPR-Cas9 genome editing and assessed the impact on BRD9 degradation