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While B-12 injections are not a direct weight loss solution, they can contribute to an overall healthier metabolism and increased energy levels, which may indirectly support weight management efforts

Until the recent breakthrough on preparation of 15 N-labeled cobalamins via biosynthesis [8] and further development of the first multiple stable isotope dilution assay (SIDA) that simultaneously determines the four natural vitamers [7], the quantification of B12 in foods has been relying on methods mainly applying microbiological assays [9, 10], (U)HPLC-UV [11,12,13,14,15,16,17], and occasionally LC-ICP-MS [18]

PMID 16702112

Theres no long-term human safety data