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Beyond QT syndromes, catecholaminergic polymorphic ventricular tachycardia (CPVT) models carrying RYR2 or CASQ2 mutations show spontaneous Ca waves and DADs under adrenergic stimulation, ameliorated by dantrolene or gene therapy 19,109 , and Brugada syndrome ( SCN5A ) models display reduced sodium currents, impaired conduction, and phase 2 reentry-like abnormalities 110