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Furthermore, APOE4 directly promotes cerebral iron accumulationpositively correlated with cognitive declinethereby amplifying neurotoxicity and contributing significantly to AD incidence (200, 201)

There is a small movement of the Tyr10 side chain, resulting in a movement of 0.7 between the OH atom positions

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PCs also inhibited nuclear factor-jB nuclear translocation and decreased eukaryotic translation initiation factor-2, phosphorylation of protein kinase RNA-like ER kinase, inositol-requiring protein-1, p38, and c-Jun N-terminal kinase in the brains of lead-exposed rats