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Description

Production of PIP 3 enables phosphorylation of Akt at threonine 308 (T308) by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and at serine 473 (S473) by the mechanistic target of rapamycin complex 2 (mTORC2)

R3 is an amino acid selected from isoleucine, leucine and valine

1:502:00 pm CDT 1966-LB Efficacy and Safety of Semaglutide 7.2 mg in ObesitySTEP UP Trial Sunday, June 22

As FOXO4 is a transcription factor, this nuclear localization indicates higher transcriptional regulatory activity, suggesting FOXO4 activity is involved in Leydig cells senescence