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Metabolomics analysis of Al 2 O 3 NPs treated HBE cells GC/TOFMS analysis was performed using an Agilent 7890 gas chromatography system coupled with a Pegasus 4D time-of-flight mass spectrometer

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Paired single-nucleus (sn) RNAseq analysis was performed on a subset of biopsies (control, NASH F0-1, NASH F2-3, NASH F4

It should be noted that besides BACE-1, a close homolog BACE-2 is also identified but there is no clear evidence relating any cleavage activities of this secretase in human APP protein