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6 Conclusion and Perspective Delayed wound healing of diabetic ulcers involves multiple pathological mechanisms, including peripheral nerve and blood vessel injury and increased inflammation cascades

APE1 is therefore considered to be neuroprotective because of its dual role in oxidative DNA damage and redox regulation (Copped, APE1 is upregulated in motor neurons of ALS patients compared to age-matched controls (Shaikh and Martin, 2002)

Radak Z, Zhao Z, Goto S, Koltai E

Nakladal D, Lambooy SPH, Mith S et al (2022) Homozygous whole body Cbs knockout in adult mice features minimal pathology during ageing despite severe homocysteinemia