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Moreover, kynurenine competes with other amino acids, such as methionine and leucine, that are transported by Slc7a5 to T cells, thereby impairing T cell-mediated immune responses [284]

The bottom line on safety: The TRAVERSE trial (2023) the largest cardiovascular safety trial of TRT to date, with 5,204 men followed for a mean of 33 months found no increased risk of major adverse cardiac events at therapeutic doses

It is worth mentioning that all measurements were repeated thrice, and the obtained values were reported as mean standard deviation

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