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G6PD deficiency which reduces NADPH production phenocopies GSR impairment for exactly this reason: less NADPH means less GSR-driven GSSG reduction, less available GSH, and more oxidative stress under equivalent ROS production

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Annu Rev Biochem 87:10151027 Corina A, Rangel-Ziga OA, Jimnez-Lucena R, Alcal-Daz JF, Quintana-Navarro G, Yubero-Serrano EM, Lpez-Moreno J, Delgado-Lista J, Tinahones F, Ordovs JM (2019) Low intake of vitamin E accelerates cellular aging in patients with established cardiovascular disease: the CORDIOPREV study

Following compression injury, however, microglial processes often extend through the glial limitans into the injured meningeal space (white arrows) as evidenced by the presence of microglial processes adjacent to the skull bone (blue)