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whether contrast-induced oxidative stress acts as a direct trigger, or if other intermediates (e.g., endoplasmic reticulum stress and mitochondrial dysfunction) are involved, requires definitive validation

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Depletion of cystine/cysteine reduces intracellular GSH levels and GPX4 activity within the cystine/cysteine-GSH-GPX4 axis, thus causing ferroptosis (18,99)