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The Australian registered medicine, HYDROXO-B12 hydroxocobalamin chloride 1mg/1mL injection ampoule (AUST R: 161606) Active ingredients: hydroxocobalamin chloride Dosage form: Injection, Solution Sponsor: Aspen Pharmacare Australia Pty Ltd is currently in shortage due to manufacturing issues

A study showed that hyperhomocysteinemia represents 510 % of all thrombotic episodes and MTHFR C677T variant homozygosity is strongly associated with pregnancy complications and severe pregnancy outcomes (12)