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It has also been shown that c-Met/PI3K/Akt signaling is responsible for resistance to photodynamic therapy and doxorubicin in carcinomas via enhancement of BCRP/ABCG2 expression [88]

Fisetin The senolytic activity of Fisetin, a flavonoid polyphenol, has been discovered during an in vitro screen of different polyphenols and its activity has been confirmed in vivo by analyzing the evolution of senescent cells accumulation in progeroid mice 19