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Mitochondria, which are central to cellular energy production and signaling, generate both adenosine triphosphate (ATP) and ROS such as O 2 and H 2 O 2 through electron transfer reactions

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Microglia are transformed into DAM by recognizing Neurodegeneration-Associated Molecular Pattern (NAMP) danger signals which leak from damaged neuronal cells in analogy to the peripheral immune systems pathogen- and damage-associated stress signals (PAMPs and DAMPs) 23