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J Trans Med (2010) 8:93

Two anthelminticantioxidant combinations, praziquantel-resveratrol [combination index (CI) = 0.74] and artesunate-resveratrol (CI = 0.34) displayed moderate and strong synergy, respectively

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By contrast, the presence of the inhibitor forces the Tyr296 side chain to a closed conformation, hindering the NADPH attachment, and leading to enzyme inhibition