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Hereditary causes include genetic defects in the metabolism of amino acids, cholesterol, and fatty acids, such as propionyl-CoA carboxylase deficiency (aka propionic acidemia) and medium chain acyl-CoA dehydrogenase deficiency (36)

Lipid Res

While this maldistribution promotes astrocyte swelling, alternative evidence identifies the initial pathology as arising from disrupted astrocytic potassium buffering (Eid and Lee 2013)