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In addition, the discovery of the first specific LDHB inhibitor was recently reported 61

DL-Threo- -benzyloxyaspartate (TBOA) is a glutamate uptake blocker frequently used to induce excitotoxicity

Despite RIC is classified as an autosomal recessive disorder, five of the seven Japanese patients with RIC in a retrospective study were compound heterozygous, and two were simple heterozygous with a single variant of the ATP8B1 or ABCB11 genes