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[1] Because intrinsic-factor-dependent uptake in the distal ileum can be absent in conditions such as autoimmune gastritis, pancreatic insufficiency, or bariatric surgery, the intramuscular or subcutaneous route bypasses gastrointestinal barriers and reliably restores serum concentrations

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GLP-1s work by suppressing appetite, slowing gastric emptying, and improving insulin sensitivity in ways that compound over months of consistent use

It also influences the pancreas by promoting the release of digestive enzymes, further enhancing the breakdown of food and nutrient processing in the intestine