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Investigation into the correlation between the structure of hydroxypyridinones and bloodbrain barrier permeability

Kim Y, Huang X, Suga S, Mazzali M, Tang D, Metz C, Bucala R , Kivlighn S, Johnson R, Lan H

A., Makrantonaki, E., & Zouboulis, C

Discontinuation Rates Discontinuation rates due to adverse events in the Phase 2 trial were dose-dependent, ranging from approximately 6% in the 1 mg arm to 16% in the 12 mg arm