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Among them, the endothelium-dependent relaxation function of mice on a high-cholesterol diet was impaired at the 8th and 12th weeks

Similar content being viewed by others Main Over the course of millennia, cells have evolved sophisticated defense pathways to maintain their homeostasis against external perturbations 1 , which typically involve sequestering 2 , degradation 3 and clearance of the toxins 4

Collectively, the phenomena of gut dysbiosis are directly involved in the exacerbated inflammatory responses related to IBD via direct interactions with the immune system or through the production and release of toxins/microbial metabolites with potential immunomodulatory effects [39]