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This is notable because PHGDH and PSAT1 are heavily lactoylated and LGSH inhibits PHGDH activity (35

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Interestingly and in contrast to CHAC1, CHAC2 is not localized to the mitochondria (Ward et al., 2024)

Its triple GIP/GLP-1/glucagon agonist mechanism produced the most striking weight-loss numbers ever reported in a Phase 2 trial of an injectable peptide, and its broad TRIUMPH Phase 3 program is poised to expand understanding of how triple receptor modulation affects obesity, diabetes, liver disease, cardiovascular risk, sleep apnea, and musculoskeletal health