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This event occurs through epigenetic modification, which represents a rapid and reversible response and involves diverse enzymes including histone (de)methylases, (de)acetylases, and DNA

The combination of these two measures can reveal a link between cochlear neuropathy and central neural hyperactivity, providing characteristic evidence that cochlear synaptopathyseen as a reduction in wave-I amplitudeis followed by compensatory central gain, reflected in the relatively stable amplitude of wave V 11,45

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3.) Maturation stage: A mature biofilm is formed, consisting of hyphal cells, pseudohyphal cells and round yeast cells, forming a complex network, wrapped by the extracellular matrix, presenting a thick and clear structure