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Compared with those in the control group, the expression of three genes ( PIK3R1 , HIF-1A , and MAPK1 ) was upregulated and that of TLR-4 was downregulated in L-carnitine-treated group, as shown in Figure 8

10.1016/j.ccell.2014.09.003 312

Acknowledgments The illustration in Figure 1

Mitochondrial Origin = Metabolic Power Unlike typical peptides, MOTSc is synthesized in response to cellular energy demandsparticularly when glucose is scarce or when the body is under stress