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Elevated levels of oxidative stress in ASD cause increased GSH depletion, which disrupts the dynamic balance between GSH and GSSG

120 mM monopotassium glutamate

[5] previously evaluated the separate roles of insulin and IGF-1 in directly regulating GH secretion, using the Cre/loxP system to knock down the insulin receptor (INSR) and IGF-1 receptor (IGFIR) in primary mouse pituitary cell cultures