glutathione depletion cancer Deubiquitinases Maintain Protein Homeostasis and Survival of Cells upon Depletion: Cell Metabolism Glutathione-Dependent Pathways in Cancer Cells

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Increased expression of Bax, caspase-3, and caspase-9, as well as decreased levels of Bcl-2, matrix metallo-proteinase-9 (MMP-9), and -catenin siRNA, were associated with the induction of apoptosis and inhibition of cell proliferation ( DATS treatment induced cell cycle arrest (G2/M phase) and apoptosis, which drastically reduced MCF-7 cell viability and not affected the MCF-12A normal human breast epithelial cells

The thiol group in proteins can usually be oxidized in the following ways, where GSH is glutathione, GSSG is glutathione disulfide, RSH is a protein containing a thiol group with R being the protein residue