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Asamura, H, Nishimura, KK, Giroux, D, Chansky, K, Hoering, A, Rusch, V, Rami-Porta, R, Araujo, LH, Beer, D, Bertoglio, P, Beyruti, R, Bill, A, Boubia, S, Brambilla, E, Cangir, AK, Carbone, DP, Cilento, V, Connolly, C, Darling, G, Detterbeck, FC, Dibaba, DT, D'Journo, XB, Donington, J, Eberhardt, WE, Edwards, J, Erasmus, JJ, Fang, W, Fennell, D, Fong, K, Galateau-Sall, F, Gautschi, O, Gill, RR, Giroux, D, Giuliani, M, Goo, JM, Hasegawa, S, Hirsch, F, Hoffman, H, Hofstetter, WL, Huang, J, Joubert, P, Kernstine, K, Kerr, K, Kim, YT, Kim, DK, Kindler, HL, Lievens, Y, Liu, H, Rice, DC , Wistuba, II

Excess copper reacts easily with oxygen, creating reactive oxygen species (ROS) tiny sparks that damage cell membranes and proteins if not neutralized in time

CS exposure causes both the release of proinflammatory cytokines and a large number of reactive oxygen species (ROS), leading to the damage of both oxidative and aggravating inflammation, thus resulting in the morphological changes in emphysema after long-term exposure

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