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Unlike most peptides that act through cell surface receptors, its small molecular size allows it to cross cellular and nuclear membranes, potentially binding directly to DNA or histone proteins to influence gene expression [3] [1] [2]

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Aim: To identify the association of cerebral vasoreactivity (CVR) by transcranial Doppler (TCD) to predict PSCI at 12 months Methods: Prospective, longitudinal, multicenter study, of incident cases of adult patients with acute stroke, without previous cognitive impairment