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A randomized phase II trial of MEK and CDK4/6 inhibitors vesus tipiracil/trifluridine (TAS-102) in metastatic KRAS/NRAS mutant (mut) colorectal cancer (CRC)

GSH can be exhausted via inhibiting SLC7A11 by traditional drugs (e.g., sorafenib and sulfasalazine (SAS)) or novel compounds (e.g., erastin), thus inducing ferroptosis (Dixon et al., 2012,2014)

Particularly in progressive MS, active inflammatory lesions detected by MRI are rare, and instead, patients have widespread lowgrade inflammation behind an intact BBB (149)