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Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections

NRF2 controls many of the enzymes that participate in glutathione synthesis and metabolism, including the catalytic and regulatory subunits of glutamate-cysteine ligase (GCLC/GCLM), glutathione synthase (GSS) and the subunit of the cystine/glutamate transporter xCT (SLC7A11), all of which are required for glutathione synthesis (Kwak et al., 2002

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Many ROS are examples of what we call free radicals atoms or molecules with unpaired electrons that makes them highly reactive