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The phase III clinical trial in newly diagnosed GBM demonstrated a significant increase in overall survival by 4.9 months when combined with TMZ, in comparison to patients receiving TMZ alone (20.9 months and 16.0 months, respectively), resulting in the FDA approval of TTFields for GBM in 2015 (29)

For each treatment with a sample size of at least 20, the NAS for the overall condition or a specific symptom was then compared to that provided by patients for a Vitamin C supplement (oral, nonliposomal) as a reference