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Knowing the treatment options for anemia that cause swollen legs is vital

Cycling of vitamin B12 requires both FMN and FAD for the enzyme methionine synthase reductase, and FAD for Methylene-tetrahydrofolate reductase, and so in functional B2 deficiency there will also be functional B12 deficiency, particularly for Methyl B12, which is central to the production of the methylation compound S-Adenosylmethionine (SAM)