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Overexpression of HNP-1, a type of -defensin, promotes the proliferation and activation of HSCs (86)

For example, melanoma-associated antigen A (MAGEA), which belongs to a class of cancer-testis antigens whose promoters are known to be methylated in healthy tissues (except for testis), is initially silenced through hypermethylation, but its promoters can be activated through demethylation, leading to increased tumor aggressiveness in lung, breast and colorectal cancers [13, 75, 76]

Bottero V, Potashkin JA (2020) A comparison of gene expression changes in the blood of individuals consuming diets supplemented with olives, nuts or long-chain omega-3 fatty acids

Moreover, oncolytic bacterial or oncolytic virotherapy may convert tumor sites into localized, destructive infections, 411 which, if mishandled, may result in severe infections or life-threatening consequences